Posts Tagged by health writer
|June 23, 2016||Posted by Anharris under HarrisCom News, Health, Highlight 2, Innovation, Life Science, Technology|
Anita Harris and Linda Grace Kobas of the Harris Communications Group played key roles in the writing and editing of “Convergence: the Future of Health,” a report released today by the Massachusetts Institute of Technology (MIT).
The Convergence report is aimed at accelerating a “Convergence Revolution,” in which the tools, technologies, methods and insights of physical sciences, information technology and engineering are increasingly being employed in the life sciences to transform biomedicine, promising to enhance human health and well-being.
The Convergence report was chaired by Susan Hochfield, former president of MIT and a neuroscientist; Tyler Jacks, Director of the David H. Koch Institute for Integrative Cancer Research at MIT; and Nobel Prize Laureate Phillip Sharp, Institute Professor at MIT.
“It was a privilege to work with such a brilliant team on a project that holds the potential to transform biomedicine in the US,” Harris said.
The Convergence report draws on insights from several dozen expert participants at two workshops, as well as input from scientists and researchers across academia, industry, and government. It includes a wide range of recommendations for advancing convergence research, but emphasizes one critical barrier above all: the shortage of federal funding for convergence fields.
As Sharp explained, “Convergence science has advanced across many fronts, from nanotechnology to regenerative tissue. Although the promise has been recognized, the funding allocated for convergence research in biomedical science is small and needs to be expanded. In fact, there is no federal agency with the responsibility to fund convergence in biomedical research.”
The National Institutes of Health (NIH) are the primary source of research funding for biomedical science in the United States. In 2015, only 3 percent of all principal investigators funded by NIH were from departments of engineering, bioengineering, physics, biophysics, or mathematics. Accordingly, the report calls for increasing NIH funding for Convergence research to at least 20 percent of the agency’s budget.
Harris, aided by MIT graduate and post doctoral students, wrote the sections covering education and policy; a second author, Al Hammond, a former editor at Science Magazine, wrote the scientific and technical sections. Linda Grace-Kobas, former Cornell University News Director and a member of the Harris Communications Group, served as copy editor. Kate Stoll of the MIT Washington office was the project manager.
A forum on “Convergence: the Future of Health” will be held at the National Academies of Sciences, Engineering and Medicine in Washington, DC, on Friday, June 24.
The report is available at http://www.convergencerevolution.net/2016-report .
The Harris Communications Group is an award-winning PR and marketing firm based in Cambridge, MA. Managing Director Anita M. Harris is a former journalist who covered health, science and technology for the MacNeil/Lehrer Report (now the NewsHour) of PBS. Linda Grace Kobas, also a former science journalist, served for many years as the Cornell University News Director
|October 30, 2012||Posted by Anharris under Client Releases, Cool Companies, Health, Life Science, Press Releases|
The studies, which have already starting enrolling in the U.S., aim to confirm the disease-modifying effects seen in the Phase 2 studies in mild to moderate patients over an 18-month timeframe. The first study will involve 833 people with mild to moderate Alzheimer’s disease over 12 months.2 The second study will include 500 people with mild Alzheimer’s disease over 18 months.3
The study drug, LMTX™, is a second-generation TAI that targets the Tau tangles and their precursors, dissolving them in order to halt their harmful effects on memory.4-6 LMTX™ also works on the early stage Tau aggregates (called ‘oligomers’) which are precursors to fully-formed tangles and are thought to be particularly toxic.7
“Clinicians devoted to Alzheimer’s disease have been waiting for a promising agent with disease-modifying properties,” said Professor Serge Gauthier of the McGill Centre for Studies in Aging, Quebec, Canada. “The basic science data for this agent, particularly in the tauopathies, looks sound and the interest among investigators and among families is high.” Professor Gauthier is a clinical investigator and scientific advisor for TauRx.
The tangles in the brain were first reported by Dr. Alois Alzheimer in 1907,8 starting the century-long journey to understand the pathology leading to their formation, their role in dementia, and, ultimately, how to stop their spread through the brain.
Professor Lon Schneider, MD, of the Keck School of Medicine at the University of Southern California, a scientific advisor for TauRx, said: “Successfully targeting Tau may be an important approach towards slowing and ideally halting the neuro-degeneration that is characteristic of Alzheimer’s disease or frontotemporal dementia. Clinicians need these Phase 3 studies to produce clear evidence that such an approach could lead to improved patient outcomes.”
Countries in which the Phase 3 clinical trials will be conducted include Australia, Belgium, Canada, Finland, France, Germany, Italy, Russia, Spain, Netherlands, Singapore, Malaysia, Taiwan, U.S., and U.K. Patients and caregivers are invited to sign up for study updates at www.AlzheimersStudies.com, as the clinical trials are initiated in the countries selected.
About Alzheimer’s Disease and Tau Tangles:
Alzheimer’s disease is one of the most important health challenges worldwide, and the most-common type of dementia. According to the Geneva-based World Health Organization, global dementia cases are expected to double within 20 years to an estimated 65.7 million people [more than the entire population of France currently at 63 million people].9 In very early, asymptomatic Alzheimer’s, pre-tangle Tau aggregates (oligomers) and Tau protein tangles are already present in the same regions of the brain where neuronal degeneration and loss of neuronal cells eventually occur.10,11 These changes first appear 20 – 30 years before the disease becomes clinically evident. With time, Tau tangles spread from the entorhinal cortex (responsible for learning, memory, thinking and planning) through the hippocampus to the neocortex (affecting the ability to communicate, recognize family and loved ones and to care for oneself), resulting in neuronal dysfunction and worsening of clinical symptoms.11 The spread is now thought to be due to a prion-like process whereby the oligomers act as ‘infectious particles’ which are able to propagate the abnormal aggregation of Tau protein from one neurone to the next.12 These oligomers recruit normal Tau to produce yet more infectious oligomers which spread neuronal destruction throughout the brain.
About TauRx Therapeutics:
TauRx Therapeutics Ltd was established in Singapore in 2002 with the aim of developing new treatments and diagnostics for a range of neurodegenerative diseases based on an entirely new approach which targets aggregates of abnormal fibres of Tau protein that form inside nerve cells in the brain, giving rise to Tangles. The TauRx team have since discovered that LMTX™ could also have beneficial effects in several other neurodegenerative diseases associated with Tau pathology, as well as other protein aggregation disorders including Parkinson’s, Huntington’s, Frontotemporal Dementia [FTD-Pick’s Disease], Progressive Supranuclear Palsy and Cortico-Basal Degeneration. While TauRx corporate headquarters are in Singapore, its primary research facilities are in Aberdeen, Scotland.
For press enquiries please contact:
U.S. media contacts:
Anita Harris +1 617-576-0906 email@example.com
Outside the U.S. media contacts:
Sylvie Berrebi +44 (0)7795 197271 /+44 (0)7973 950376
Elizabeth Puller +44 (0)208 834 1447
Email: after Oct. 29:
- Wischik CM, Bentham P, Wischik DJ, Seng KM. Tau aggregation inhibitor (TAI) therapy with remberTM arrests disease progression in mild and moderate Alzheimer’s disease over 50 weeks. Alzheimer’s and Dementia 2008;4:T167. Abstract available at: http://www.alzheimersanddementia.com/article/S1552-5260(08)00598-0/fulltext. Accessed October 2012.
- ClinicalTrials.gov. Safety and efficacy study evaluating TRx0237 in subjects with mild to moderate Alzheimer’s disease. Available at: http://www.clinicaltrials.gov/ct2/show/NCT01689246. Accessed October 2012.
- ClinicalTrials.gov. Safety and efficacy study evaluating TRx0237 in subjects with mild Alzheimer’s disease. Available at: http://www.clinicaltrials.gov/ct2/show/NCT01689233. Accessed October 2012.
- Wischik CM, Edwards PC, Lai RYK, Roth M, Harrington CR. Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Proc Natl Acad Sci USA 1996;93:11213-11218. Full article available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC38310/. Accessed October 2012.
- Wischik CM, Lai RYK, Harrington CR. Modelling prion-like processing of tau protein in Alzheimer’s disease for pharmaceutical development. In: Brain Microtubule Associated Proteins: Modifications in Disease, eds. Avila J, Brandt R, Kosik KS. (1997) pp. 185-241. Amsterdam: Harwood Academic Publishers.
- Wischik CM, Wischik DJ, Storey JMD, Harrington CR. Rationale for tau-aggregation inhibitor therapy in Alzheimer’s disease and other tauopathies. In: Emerging Drugs and Targets for Alzheimer’s Disease. Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism, ed. Martinez A. (2010) pp. 210-232. Cambridge: RSC Publishing.
- Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, et al. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J Biol Chem 2005;280:7614-7623. Full article available at: http://www.jbc.org/content/280/9/7614.long. Accessed October 2012.
- Alzheimer A. On a peculiar disease of the cerebral cortex. Allgemeine Zeitschrift für Psychiatrie und Psychisch-Geritlich Medicin 1907;64:146-148.
- World Health Organization News Release. Dementia cases set to triple by 2050 but still largely ignored. Available at: http://www.who.int/mediacentre/news/releases/2012/dementia_20120411/en/index.html. Accessed October 2012.
- Mukaetova-Ladinska EB, Garcia-Sierra F, Hurt J, Gertz HJ, Xuereb JH, Hills R, et al. Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer’s disease. Am J Pathol 2000;157:623-636. Full article available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850134/. Accessed October 2012.
- Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-259. Abstract available at: http://www.ncbi.nlm.nih.gov/pubmed/1759558. Accessed October 2012.
- Soto C. Transmissible proteins: expanding the prion heresy. Cell 2012; 149:968-977. Full article available at: http://www.sciencedirect.com/science/article/pii/S0092867412005818. Accessed October 2012.